Investigating the Genetic Background of Proteoglycan- Induced Arthritis and Proteoglycan-Induced Ankylosing Spondylitis
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Investigating the Genetic Background of Proteoglycan-Induced Arthritis and Proteoglycan- Induced Ankylosing Spondylitis
Introduction: The MHC (H-2d) and non-MHC genetic background make the BALB/c strain highly susceptible to inflammatory arthritis and spondylitis. Although different BALB/c colonies develop proteoglycan (PG)-induced arthritis (PGIA) and spondylitis (PGIS) in response to immunization with human cartilage PG, they show significant differences in disease penetrance, despite being maintained by the s...
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تاریخ انتشار 2010